ABSTRACT
<p><b>OBJECTIVE</b>To explore the feasibility of C1-2 pedicle screw fixation and fusion technique in treating atlantoaxial instability.</p><p><b>METHODS</b>From January 2006 to January 2009,18 patients with atlantoaxial instability were treated with C1-2 pedicle screws and plates fixation under general anesthesia. There were 11 males and 7 females, the age for 17-62 years with the mean of 37.7 years. The course of disease was from 3 days to 30 months with an average of 10.6 months. The patients had different degrees neck pain and disturbance of sensation or (and) dyskinesia, had atlantoaxial instability from images before operation. The JOA scoring before operation were from 8 to 15 with an average of 11.4. Bone fusion of patients was observed with X-rays, CT and MR image at the same time after operation and the JOA scoring was compared with preoperative.</p><p><b>RESULTS</b>A total of 72 screws were successfully placed in 18 cases, among them, 15 cases were followed up from 6 to 24 months with an average of 11.5 months. Fifteen cases obtained bone fusion with time for 3-6 months without the complications of internal fixation failure or redislocation of atlas. The spinal compression had differently improved, postoperative JOA scoring was from 12 to 17 scores with an average of 14.5 scores.</p><p><b>CONCLUSION</b>Pedicle screw fixation and fusion in atlas has advantages of firm fixation and high fusion rate, it is a better choices for atlantoaxial instability. It is not suitable for variations of sulcus of vertebral artery of atlas and posterior arch of atlas.</p>
Subject(s)
Adolescent , Adult , Female , Humans , Male , Middle Aged , Young Adult , Atlanto-Axial Joint , Wounds and Injuries , General Surgery , Bone Plates , Bone Screws , Fracture Fixation, Internal , Treatment OutcomeABSTRACT
Glial scar formed by central nervous system (CNS) injury is the main inhibitory barrier of nerve regeneration. How to promote axonal regeneration after injury,how to accelerate neural network reconstruction and how to improve brain function recovery have become a hot problem to be solved in the field of neuroscience. This article focuses on the recent advances of therapeutic strategies for axonal regeneration.
Subject(s)
Animals , Humans , Astrocytes , Pathology , Brain Injuries , Pathology , Cicatrix , Nerve Regeneration , Neuroglia , Pathology , Neuronal Plasticity , Physiology , Neurons , Physiology , Proteoglycans , Metabolism , Spinal Cord Injuries , PathologyABSTRACT
<p><b>OBJECTIVE</b>To explore the clinical features, treatment and prognosis of the C5 palsy after surgery of cervical spondylosis.</p><p><b>METHODS</b>Two hundred and twenty-three cases treated from March 1994 to October 2003 were retrospectively reviewed.</p><p><b>RESULTS</b>Seven of the 223 cases developed the complication of C5 palsy, manifesting the paresis of the deltoid muscle as well as the sensory deficits and (or) intractable pain in shoulder. The incidence was 3.1%. In this study, 2 cases occurred in the anterior subcorpectomy, 5 cases developed in the laminoplasty with 1 case on the opened side, 3 cases on the hinged side and 1 case on both sides. All the 7 cases with the C5 palsy recovered within 2 weeks to 6 months.</p><p><b>CONCLUSION</b>The C5 palsy can develop either anterior decompression or posterior open-door laminoplasty of cervical spondylosis. Generally speaking, patients with postoperative C5 palsy can be cured by conservative measures. And prognosis is good.</p>